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2012
ACL
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M.Fatnassi, C.Tourné-Péteilh, T.Mineva, J.M.Devoisselle, P.Gaveau, F.Fayon, B.Alonso, 'Drug nano-domains in spray-dried ibuprofen–silica microspheres', Phys. Chem. Chem. Phys. 14 12285-12294 (2012) doi:10.1039/c2cp42092a
Spray-dried silica microspheres encapsulating ibuprofen in nano-domains have been studied by solid-state NMR (experiments, calculations). Ibuprofen molecules are mobile, interacting through hydrogen bonds, and solely forming the nano-domains which diameters are estimated to be 40 nm.
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